New research indicates that patients who discontinue new GLP-1 drugs like Wegovy and Mounjaro can put back on shed pounds far faster than those who end conventional diet and exercise regimens.
Research printed in a prominent health publication points out that while obese people can lose substantial amounts of their body weight while using the jabs, the mass is regained at an average rate of 0.8 kg per month after stopping.
"Users purchasing such drugs need to be aware of the danger of quick rebound weight gain when the treatment is stopped," warns lead investigator Dr. Susan Jebb.
Such speed of regain suggests a return to pre-treatment weight in about one and a half years.
Comparing Treatments
The analysis, which looked at 37 of trials involving thousands of patients, compared the results of GLP-1 agonists with conventional dieting.
Scientists emphasize that individuals who shed pounds through lifestyle changes alone typically experience a more gradual creep back—perhaps 0.1 kg a month—post-intervention.
Understanding the Quick Regain
Nutrition scientists believe the mode of action of the jabs is key to understanding the accelerated regain.
The injections copy a natural hormone called GLP-1, which moderates hunger.
"Artificially providing the hormone levels several times higher than normal might result in the body to produce less of its endogenous hormone, and could reduce sensitivity to its effects," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this medication results in appetite is uncontrolled, making overeating much more probable."
A Chronic Condition?
The NHS advise the injections for people with obesity-related health risks, alongside recommended diet and exercise modifications.
Many experts say that, given the likelihood of relapse, the therapy is often ongoing.
This opinion is reinforced by pharmaceutical companies, who say that the results "highlight the persistent nature of obesity," similar to managing conditions like diabetes.
Patient Testimonies
People who have discontinued the jabs explain a sudden return of hunger.
"It was like something activating and you become starving," said an individual.
This difficulty is exacerbated if users have not developed sustainable lifestyle or habit changes during therapy.
Widespread Use
Recent estimates suggest that a significant number of people in the UK have used weight-loss jabs in the past year, with desire continuing to grow.
- Adoption is higher among females compared to males.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
In conclusion, experts caution that while these medications are effective agents for shedding pounds, they are not a magic fix and long-term success hinges on ongoing behavioural support.
